Opioids

Terms to know

  • Opioids Are a class of natural, semi-synthetic, and synthetic drugs. They are addictive, differ in potency, and are a major driver of the drug overdose crisis in the United States.
    • Natural opioids- are made from the seed pods of the opium poppy plant (aka opiates). Examples include morphine, codeine, and opium.
    • Semi-synthetic opioids- are made in laboratories by chemically processing natural opioids. Examples include heroin and the prescription opioids oxycodone, hydrocodone, and oxymorphone.
    • Synthetic opioids- are manufactured entirely in laboratories with no natural ingredients. An example is fentanyl, which is 50-100 times more potent than morphine.
  • Opioid use disorder (OUD): A problematic pattern of opioid use that causes significant impairment or distress.
  • Prescription drug misuse means taking a medication in a manner or dose other than prescribed. Examples of misuse include:
    • Taking too much, or too often, or too long.
    • Using it for something it wasn’t prescribed for- to get high, to relieve tension, sleep, or be alert or study.
    • Taking a medication that wasn’t prescribed to you- getting it from a family member or friend.
    • Taking it in a way other than directed (such as crushing pills).
    • Taking it with alcohol or other drugs.
  • Fake pills Criminal drug networks are mass-producing and marketing fake pills look just like real medications.
    • Fake pills often contain fentanyl and can be deadly
    • Often sold on mainstream social media sites and websites to anyone- including kids.
  • Overdose occurs when a person takes a higher drug dose than their body can handle.
    • Opioids affect the brain centers that control breathing. When a person takes a high dose of an opioid, breathing can slow to life-threatening levels.

Current statistics

Source- 2023 Companion Infographic Report: Results from the 2021, 2022, and 2023 National Surveys on Drug Use and Health (pg. 8)

For additional statistics, click here.

Fentanyl facts

Source- EPCPH

For more Fentanyl facts, click here and here.

Health risks using opioids

Opioid use, even as prescribed by a health care provider or only for a short time, can lead to negative health effects.

  • Opioids are addictive. 
  • High doses can lead to overdose, severe brain damage, and/or death.
    • Taking opioids with other drugs raises the likelihood of harm.
  • Opioids can cause unpleasant effects when taken for a long time. Symptoms include constipation, nausea and vomiting, headache, dizziness, and sleepiness or sleep problems.
  • Opioids can cause cardiovascular changes, such as slower heart rate, low blood pressure, heart failure, and cardiac arrest.
  • Opioids can impair the immune system, increasing risk of infection.
  • Opioid use in higher doses and longer times can cause changes in a person’s body that can actually make them more sensitive to pain.
  • Opioid use also has been associated with mental disorders like depression or sexual dysfunction.
  • People who inject opioids are at an increased risk of diseases caused by viruses such as hepatitis C or human immunodeficiency virus (HIV). 
    • They also may develop bacterial infections that cause inflammation of the heart’s inner lining (endocarditis).

Source- NIDA

For information about opioids and pregnancy, click here and here.


Signs of having opioid use disorder

  • Consuming the drug in larger amounts or for longer than intended.
  • Persistently wanting to cut down or regulate drug use.
  • Spending a great deal of time obtaining, using, or recovering from the effects of the drug.
  • Experiencing a strong desire to use the drug (craving).
  • Failing to fulfill major obligations at work, school, or home because of drug use.
  • Continuing drug use even if it causes significant social or interpersonal problems.
  • Reducing or stopping other activities because of drug use.
  • Repeatedly using the drug in situations when it is unsafe.
  • Continuing drug use even when knowing that it causes physical or psychological problems.
  • Developing tolerance.
  • Experiencing withdrawal symptoms when stopping drug use.

Source- NIDA


Signs of an overdose

Several signs can indicate that a person is experiencing an overdose and requires immediate medical attention:

  • Unconsciousness or inability to wake up.
  • Limp body
  • Slow or shallow breathing or difficulty breathing.
  • Choking or gurgling sounds
  • Small, constricted “pinpoint” pupils that don’t react to light.
  • Pale, blue, or cold skin
  • Purple lips and fingernails
  • Faint heartbeat
  • Vomiting

Source- NIDA and Medline Plus


What should I do if I think someone is overdosing?

If you suspect someone is overdosing…

  • Call 911.
  • Use naloxone, if it is available.
  • Try to keep the person awake and breathing.
For more information, click here.

Prevention- Knowledge is power

Parents and caregivers
Community members and agencies

Need Help?

For mental or substance use disorders, call SAMHSA’s National Helpline at 1-800-662-HELP (4357) or TTY: 1-800-487-4889, or text your zip code to 435748 (HELP4U), or use the FindTreatment.gov to get help.